Cargando…

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

Resveratrol is one of the most widely studied bioactive plant polyphenols which possesses anticancer properties. Previously we have reported synthesis, characterization and identification of a novel resveratrol analog, SS28. In the present study, we show that SS28 induced cytotoxicity in several can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Elizabeth, Gopalakrishnan, Vidya, Hegde, Mahesh, Kumar, Sujeet, Karki, Subhas S., Raghavan, Sathees C., Choudhary, Bibha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066224/ https://www.ncbi.nlm.nih.gov/pubmed/27748367 http://dx.doi.org/10.1038/srep34653

Ejemplares similares

Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice
por: Hegde, Mahesh, et al.
Publicado: (2012)

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells
por: Hegde, Mahesh, et al.
Publicado: (2017)

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis
por: Srivastava, Shikha, et al.
Publicado: (2016)

Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines
por: Koroth, Jinsha, et al.
Publicado: (2019)

Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse
por: Thomas, Elizabeth, et al.
Publicado: (2016)

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models
por: Nirgude, Snehal, et al.
Publicado: (2020)

Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice
por: Somasagara, Ranganatha R., et al.
Publicado: (2012)

Acute toxicity analysis of Disarib, an inhibitor of BCL2
por: Sharma, Shivangi, et al.
Publicado: (2020)

Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice
por: Srivastava, Mrinal, et al.
Publicado: (2014)

SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining
por: Manjunath, Meghana, et al.
Publicado: (2021)

G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome
por: Kumari, Nitu, et al.
Publicado: (2019)

A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin
por: Traversi, Gianandrea, et al.
Publicado: (2019)

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest
por: Kavitha, Chandagirikoppal V., et al.
Publicado: (2013)

MiRAGDB: A Knowledgebase of RAG Regulators
por: Desai, Sagar Sanjiv, et al.
Publicado: (2022)

Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats
por: Sharma, Shivangi, et al.
Publicado: (2021)

A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins
por: Nirgude, Snehal, et al.
Publicado: (2023)

Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells
por: Chiruvella, Kishore K., et al.
Publicado: (2010)

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
por: Tadi, Satish Kumar, et al.
Publicado: (2016)

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice
por: Sharma, Anju, et al.
Publicado: (2022)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent–induced mitotic arrest
por: Tsuda, Yasuo, et al.
Publicado: (2017)

Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus
Publicado: (1979)

Curcumin derivative 1, 2-bis [(3E, 5E)-3, 5-bis [(2-chlorophenyl) methylene]-4-oxo-1-piperidyl] ethane-1, 2-dione (ST03) induces mitochondria mediated apoptosis in ovarian cancer cells and inhibits tumor progression in EAC mouse model
por: Koroth, Jinsha, et al.
Publicado: (2021)

Soluble tubulin is significantly enriched at mitotic centrosomes
por: Baumgart, Johannes, et al.
Publicado: (2019)

Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis
por: Annamalai, Pazhanimuthu, et al.
Publicado: (2015)

γ-tubulin is differentially expressed in mitotic and non-mitotic cardiomyocytes in the regenerating zebrafish heart
por: Sallin, Pauline, et al.
Publicado: (2015)

Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis
por: Mili, Donia, et al.
Publicado: (2016)

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules
por: Cesare, Erica Di, et al.
Publicado: (2017)

The crystal structure of 6-(4-chlorophenyl)-2-(4-methylbenzyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
por: Sowmya, A., et al.
Publicado: (2016)

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
por: Nambiar, Mridula, et al.
Publicado: (2011)

DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination
por: Srivastava, Shikha, et al.
Publicado: (2017)

Ultrastructural colocalization of tyrosinated and detyrosinated alpha- tubulin in interphase and mitotic cells
Publicado: (1986)

Novel Synergistic Combination of Mitotic Arrest and Promotion of Apoptosis for Treatment of Pancreatic Adenocarcinoma
por: Duan, Zhijian, et al.
Publicado: (2019)

Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models
por: Murugesan, Kalaimathi, et al.
Publicado: (2019)

Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma
por: Xiang, Qingfeng, et al.
Publicado: (2015)

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells
por: Filippi-Chiela, Eduardo C, et al.
Publicado: (2013)

The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells
por: Ambrosini, Grazia, et al.
Publicado: (2023)

TOG–tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation
por: Byrnes, Amy E., et al.
Publicado: (2017)

Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death
por: Ebisu, Haruna, et al.
Publicado: (2021)

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes
por: Zhu, Zihan, et al.
Publicado: (2023)

Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers
por: Paranjape, Amita M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9m9b4hrlhgge8ecojbdmg1cdli