The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior

During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior. While other Mena isoforms promote actin polymeriza...

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Detalles Bibliográficos
Autores principales: Balsamo, Michele, Mondal, Chandrani, Carmona, Guillaume, McClain, Leslie M., Riquelme, Daisy N., Tadros, Jenny, Ma, Duan, Vasile, Eliza, Condeelis, John S., Lauffenburger, Douglas A., Gertler, Frank B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066228/
https://www.ncbi.nlm.nih.gov/pubmed/27748415
http://dx.doi.org/10.1038/srep35298

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