Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

Loss-of-function mutations in BSCL2 are responsible for Berardinelli-Seip congenital lipodystrophy, a rare disorder characterized by near absence of adipose tissue associated with insulin resistance. Seipin-deficient (Bscl2(−/−)) mice display an almost total loss of white adipose tissue (WAT) with r...

Descripción completa

Detalles Bibliográficos
Autores principales: Dollet, L., Magré, J., Joubert, M., Le May, C., Ayer, A., Arnaud, L., Pecqueur, C., Blouin, V., Cariou, B., Prieur, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066230/
https://www.ncbi.nlm.nih.gov/pubmed/27748422
http://dx.doi.org/10.1038/srep35487

Ejemplares similares

Ejemplares similares