‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms

In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body tem...

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Detalles Bibliográficos
Autor principal: Green, Carla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066233/
https://www.ncbi.nlm.nih.gov/pubmed/27664233
http://dx.doi.org/10.1101/gad.289587.116
Descripción
Sumario:In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005–2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.

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