‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms

In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body tem...

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Detalles Bibliográficos
Autor principal: Green, Carla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066233/
https://www.ncbi.nlm.nih.gov/pubmed/27664233
http://dx.doi.org/10.1101/gad.289587.116
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author Green, Carla B.
author_facet Green, Carla B.
author_sort Green, Carla B.
collection PubMed
description In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005–2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.
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spelling pubmed-50662332017-03-01 ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms Green, Carla B. Genes Dev Outlook In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005–2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency. Cold Spring Harbor Laboratory Press 2016-09-01 /pmc/articles/PMC5066233/ /pubmed/27664233 http://dx.doi.org/10.1101/gad.289587.116 Text en © 2016 Green; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Green, Carla B.
‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title_full ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title_fullStr ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title_full_unstemmed ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title_short ‘Cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
title_sort ‘cold cuts’ added to the circadian smorgasbord of regulatory mechanisms
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066233/
https://www.ncbi.nlm.nih.gov/pubmed/27664233
http://dx.doi.org/10.1101/gad.289587.116
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