Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα

Pancreatic stromal fibroblasts provide structural support. Activated fibroblasts are critical in the tumor microenvironment. In this issue of Genes & Development, Liu and colleagues (pp. 1943–1955) unravel the finding that depletion of Smoothened (Smo) in pancreatic stromal fibroblasts results i...

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Detalles Bibliográficos
Autor principal: Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066234/
https://www.ncbi.nlm.nih.gov/pubmed/27664234
http://dx.doi.org/10.1101/gad.289272.116
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author Rustgi, Anil K.
author_facet Rustgi, Anil K.
author_sort Rustgi, Anil K.
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description Pancreatic stromal fibroblasts provide structural support. Activated fibroblasts are critical in the tumor microenvironment. In this issue of Genes & Development, Liu and colleagues (pp. 1943–1955) unravel the finding that depletion of Smoothened (Smo) in pancreatic stromal fibroblasts results in AKT activation and noncanonical GLI2 activation with subsequent TGFα secretion, activation of EGFR in pancreatic epithelial cells, and augmentation of acinar–ductal metaplasia. Additionally, Smo-mediated signaling has proproliferative effects on pancreatic tumor cells.
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spelling pubmed-50662342017-03-01 Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα Rustgi, Anil K. Genes Dev Outlook Pancreatic stromal fibroblasts provide structural support. Activated fibroblasts are critical in the tumor microenvironment. In this issue of Genes & Development, Liu and colleagues (pp. 1943–1955) unravel the finding that depletion of Smoothened (Smo) in pancreatic stromal fibroblasts results in AKT activation and noncanonical GLI2 activation with subsequent TGFα secretion, activation of EGFR in pancreatic epithelial cells, and augmentation of acinar–ductal metaplasia. Additionally, Smo-mediated signaling has proproliferative effects on pancreatic tumor cells. Cold Spring Harbor Laboratory Press 2016-09-01 /pmc/articles/PMC5066234/ /pubmed/27664234 http://dx.doi.org/10.1101/gad.289272.116 Text en © 2016 Rustgi; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Rustgi, Anil K.
Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title_full Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title_fullStr Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title_full_unstemmed Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title_short Pancreatic fibroblasts smoothen their activities via AKT–GLI2–TGFα
title_sort pancreatic fibroblasts smoothen their activities via akt–gli2–tgfα
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066234/
https://www.ncbi.nlm.nih.gov/pubmed/27664234
http://dx.doi.org/10.1101/gad.289272.116
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