Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here we show that disruption of paracrine Hedgehog signaling via genetic ablation of Smoothened (Smo) in...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Pitarresi, Jason R., Cuitiño, Maria C., Kladney, Raleigh D., Woelke, Sarah A., Sizemore, Gina M., Nayak, Sunayana G., Egriboz, Onur, Schweickert, Patrick G., Yu, Lianbo, Trela, Stefan, Schilling, Daniel J., Halloran, Shannon K., Li, Maokun, Dutta, Shourik, Fernandez, Soledad A., Rosol, Thomas J., Lesinski, Gregory B., Shakya, Reena, Ludwig, Thomas, Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, Ostrowski, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066238/
https://www.ncbi.nlm.nih.gov/pubmed/27633013
http://dx.doi.org/10.1101/gad.283499.116

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