Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression

Increased lipid synthesis is a key characteristic of many cancers that is critical for cancer progression. ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, is frequently overexpressed or activated in cancer to promote lipid synthesis and tumor progression. Cullin3 (CUL3), a core protein f...

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Detalles Bibliográficos
Autores principales: Zhang, Cen, Liu, Juan, Huang, Grace, Zhao, Yuhan, Yue, Xuetian, Wu, Hao, Li, Jun, Zhu, Junlan, Shen, Zhiyuan, Haffty, Bruce G., Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066239/
https://www.ncbi.nlm.nih.gov/pubmed/27664236
http://dx.doi.org/10.1101/gad.283283.116

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