Cargando…
Fabricating customized hydrogel contact lens
Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066254/ https://www.ncbi.nlm.nih.gov/pubmed/27748361 http://dx.doi.org/10.1038/srep34905 |
_version_ | 1782460452887855104 |
---|---|
author | Childs, Andre Li, Hao Lewittes, Daniella M. Dong, Biqin Liu, Wenzhong Shu, Xiao Sun, Cheng Zhang, Hao F. |
author_facet | Childs, Andre Li, Hao Lewittes, Daniella M. Dong, Biqin Liu, Wenzhong Shu, Xiao Sun, Cheng Zhang, Hao F. |
author_sort | Childs, Andre |
collection | PubMed |
description | Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young’s modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies. |
format | Online Article Text |
id | pubmed-5066254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50662542016-10-26 Fabricating customized hydrogel contact lens Childs, Andre Li, Hao Lewittes, Daniella M. Dong, Biqin Liu, Wenzhong Shu, Xiao Sun, Cheng Zhang, Hao F. Sci Rep Article Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young’s modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies. Nature Publishing Group 2016-10-17 /pmc/articles/PMC5066254/ /pubmed/27748361 http://dx.doi.org/10.1038/srep34905 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Childs, Andre Li, Hao Lewittes, Daniella M. Dong, Biqin Liu, Wenzhong Shu, Xiao Sun, Cheng Zhang, Hao F. Fabricating customized hydrogel contact lens |
title | Fabricating customized hydrogel contact lens |
title_full | Fabricating customized hydrogel contact lens |
title_fullStr | Fabricating customized hydrogel contact lens |
title_full_unstemmed | Fabricating customized hydrogel contact lens |
title_short | Fabricating customized hydrogel contact lens |
title_sort | fabricating customized hydrogel contact lens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066254/ https://www.ncbi.nlm.nih.gov/pubmed/27748361 http://dx.doi.org/10.1038/srep34905 |
work_keys_str_mv | AT childsandre fabricatingcustomizedhydrogelcontactlens AT lihao fabricatingcustomizedhydrogelcontactlens AT lewittesdaniellam fabricatingcustomizedhydrogelcontactlens AT dongbiqin fabricatingcustomizedhydrogelcontactlens AT liuwenzhong fabricatingcustomizedhydrogelcontactlens AT shuxiao fabricatingcustomizedhydrogelcontactlens AT suncheng fabricatingcustomizedhydrogelcontactlens AT zhanghaof fabricatingcustomizedhydrogelcontactlens |