Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise

Macrophages represent key players of the immune system exerting highly effective defense mechanisms against microbial infections and cancer that include phagocytosis and programmed cell removal. Recent findings highlight the relevance of the non-neuronal cholinergic system for the regulation of macr...

Descripción completa

Detalles Bibliográficos
Autores principales: Reichrath, Sandra, Reichrath, Jörg, Moussa, Amira-Talaat, Meier, Carola, Tschernig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066265/
https://www.ncbi.nlm.nih.gov/pubmed/27785369
http://dx.doi.org/10.1038/cddiscovery.2016.63
Descripción
Sumario:Macrophages represent key players of the immune system exerting highly effective defense mechanisms against microbial infections and cancer that include phagocytosis and programmed cell removal. Recent findings highlight the relevance of the non-neuronal cholinergic system for the regulation of macrophage function that opens promising new concepts for the treatment of infectious diseases and cancer. This mini review summarizes our present knowledge on this topic and gives an outlook on future developments.

Ejemplares similares