Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise

Macrophages represent key players of the immune system exerting highly effective defense mechanisms against microbial infections and cancer that include phagocytosis and programmed cell removal. Recent findings highlight the relevance of the non-neuronal cholinergic system for the regulation of macr...

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Autores principales: Reichrath, Sandra, Reichrath, Jörg, Moussa, Amira-Talaat, Meier, Carola, Tschernig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066265/
https://www.ncbi.nlm.nih.gov/pubmed/27785369
http://dx.doi.org/10.1038/cddiscovery.2016.63
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author Reichrath, Sandra
Reichrath, Jörg
Moussa, Amira-Talaat
Meier, Carola
Tschernig, Thomas
author_facet Reichrath, Sandra
Reichrath, Jörg
Moussa, Amira-Talaat
Meier, Carola
Tschernig, Thomas
author_sort Reichrath, Sandra
collection PubMed
description Macrophages represent key players of the immune system exerting highly effective defense mechanisms against microbial infections and cancer that include phagocytosis and programmed cell removal. Recent findings highlight the relevance of the non-neuronal cholinergic system for the regulation of macrophage function that opens promising new concepts for the treatment of infectious diseases and cancer. This mini review summarizes our present knowledge on this topic and gives an outlook on future developments.
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spelling pubmed-50662652016-10-26 Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise Reichrath, Sandra Reichrath, Jörg Moussa, Amira-Talaat Meier, Carola Tschernig, Thomas Cell Death Discov Review Article Macrophages represent key players of the immune system exerting highly effective defense mechanisms against microbial infections and cancer that include phagocytosis and programmed cell removal. Recent findings highlight the relevance of the non-neuronal cholinergic system for the regulation of macrophage function that opens promising new concepts for the treatment of infectious diseases and cancer. This mini review summarizes our present knowledge on this topic and gives an outlook on future developments. Nature Publishing Group 2016-10-17 /pmc/articles/PMC5066265/ /pubmed/27785369 http://dx.doi.org/10.1038/cddiscovery.2016.63 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Reichrath, Sandra
Reichrath, Jörg
Moussa, Amira-Talaat
Meier, Carola
Tschernig, Thomas
Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title_full Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title_fullStr Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title_full_unstemmed Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title_short Targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
title_sort targeting the non-neuronal cholinergic system in macrophages for the management of infectious diseases and cancer: challenge and promise
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066265/
https://www.ncbi.nlm.nih.gov/pubmed/27785369
http://dx.doi.org/10.1038/cddiscovery.2016.63
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