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Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066274/ https://www.ncbi.nlm.nih.gov/pubmed/27748454 http://dx.doi.org/10.1038/srep35514 |
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author | van Bergen, J. M. G. Li, X. Hua, J. Schreiner, S. J. Steininger, S. C. Quevenco, F. C. Wyss, M. Gietl, A. F. Treyer, V. Leh, S. E. Buck, F. Nitsch, R. M. Pruessmann, K. P. van Zijl, P. C. M. Hock, C. Unschuld, P. G. |
author_facet | van Bergen, J. M. G. Li, X. Hua, J. Schreiner, S. J. Steininger, S. C. Quevenco, F. C. Wyss, M. Gietl, A. F. Treyer, V. Leh, S. E. Buck, F. Nitsch, R. M. Pruessmann, K. P. van Zijl, P. C. M. Hock, C. Unschuld, P. G. |
author_sort | van Bergen, J. M. G. |
collection | PubMed |
description | Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4 (APOE-e4) allele and mild cognitive impairment (MCI) in elderly subjects. Carriers of APOE-e4 with normal cognition had higher cortical Aβ-plaque-load than non-carriers. In MCI an association between APOE-e4 and higher Aβ-plaque-load was observable both for cortical and subcortical brain-regions. APOE-e4 and MCI was also associated with higher cortical iron. Moreover, cerebral iron significantly affected functional coupling, and was furthermore associated with increased Aβ-plaque-load (R(2)-adjusted = 0.80, p < 0.001) and APOE-e4 carrier status (p < 0.001) in MCI. This study confirms earlier reports on an association between increased brain iron-burden and risk for neurocognitive dysfunction due to AD, and indicates that disease-progression is conferred by spatial colocalization of brain iron deposits with Aβ-plaques. |
format | Online Article Text |
id | pubmed-5066274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50662742016-10-26 Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment van Bergen, J. M. G. Li, X. Hua, J. Schreiner, S. J. Steininger, S. C. Quevenco, F. C. Wyss, M. Gietl, A. F. Treyer, V. Leh, S. E. Buck, F. Nitsch, R. M. Pruessmann, K. P. van Zijl, P. C. M. Hock, C. Unschuld, P. G. Sci Rep Article Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4 (APOE-e4) allele and mild cognitive impairment (MCI) in elderly subjects. Carriers of APOE-e4 with normal cognition had higher cortical Aβ-plaque-load than non-carriers. In MCI an association between APOE-e4 and higher Aβ-plaque-load was observable both for cortical and subcortical brain-regions. APOE-e4 and MCI was also associated with higher cortical iron. Moreover, cerebral iron significantly affected functional coupling, and was furthermore associated with increased Aβ-plaque-load (R(2)-adjusted = 0.80, p < 0.001) and APOE-e4 carrier status (p < 0.001) in MCI. This study confirms earlier reports on an association between increased brain iron-burden and risk for neurocognitive dysfunction due to AD, and indicates that disease-progression is conferred by spatial colocalization of brain iron deposits with Aβ-plaques. Nature Publishing Group 2016-10-17 /pmc/articles/PMC5066274/ /pubmed/27748454 http://dx.doi.org/10.1038/srep35514 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article van Bergen, J. M. G. Li, X. Hua, J. Schreiner, S. J. Steininger, S. C. Quevenco, F. C. Wyss, M. Gietl, A. F. Treyer, V. Leh, S. E. Buck, F. Nitsch, R. M. Pruessmann, K. P. van Zijl, P. C. M. Hock, C. Unschuld, P. G. Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title | Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title_full | Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title_fullStr | Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title_full_unstemmed | Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title_short | Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment |
title_sort | colocalization of cerebral iron with amyloid beta in mild cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066274/ https://www.ncbi.nlm.nih.gov/pubmed/27748454 http://dx.doi.org/10.1038/srep35514 |
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