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Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues. Still, the in vivo physiological role of circulating SHBG re...

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Detalles Bibliográficos
Autores principales:	Laurent, Michaël R., Hammond, Geoffrey L., Blokland, Marco, Jardí, Ferran, Antonio, Leen, Dubois, Vanessa, Khalil, Rougin, Sterk, Saskia S., Gielen, Evelien, Decallonne, Brigitte, Carmeliet, Geert, Kaufman, Jean-Marc, Fiers, Tom, Huhtaniemi, Ilpo T., Vanderschueren, Dirk, Claessens, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066276/ https://www.ncbi.nlm.nih.gov/pubmed/27748448 http://dx.doi.org/10.1038/srep35539

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