Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy

Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We des...

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Autores principales: Lee, Soon Jae, Cho, Yoo-Kyung, Na, Soo-Young, Choi, Eun Kwang, Boo, Sun Jin, Jeong, Seung Uk, Song, Hyung Joo, Kim, Heung Up, Kim, Bong Soo, Song, Byung-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066381/
https://www.ncbi.nlm.nih.gov/pubmed/27572075
http://dx.doi.org/10.3350/cmh.2015.0050
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author Lee, Soon Jae
Cho, Yoo-Kyung
Na, Soo-Young
Choi, Eun Kwang
Boo, Sun Jin
Jeong, Seung Uk
Song, Hyung Joo
Kim, Heung Up
Kim, Bong Soo
Song, Byung-Cheol
author_facet Lee, Soon Jae
Cho, Yoo-Kyung
Na, Soo-Young
Choi, Eun Kwang
Boo, Sun Jin
Jeong, Seung Uk
Song, Hyung Joo
Kim, Heung Up
Kim, Bong Soo
Song, Byung-Cheol
author_sort Lee, Soon Jae
collection PubMed
description Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We describe two cases of complete regression of esophageal varices and splenomegaly after interferon-alpha and ribavirin combination therapy in patients with HCV-related liver cirrhosis. Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. To our knowledge, this is the first study demonstrating that complications of liver cirrhosis, such as esophageal varices and splenomegaly, can regress after antiviral therapy in patients with HCV-related liver cirrhosis.
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spelling pubmed-50663812016-10-17 Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy Lee, Soon Jae Cho, Yoo-Kyung Na, Soo-Young Choi, Eun Kwang Boo, Sun Jin Jeong, Seung Uk Song, Hyung Joo Kim, Heung Up Kim, Bong Soo Song, Byung-Cheol Clin Mol Hepatol Case Report Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We describe two cases of complete regression of esophageal varices and splenomegaly after interferon-alpha and ribavirin combination therapy in patients with HCV-related liver cirrhosis. Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. To our knowledge, this is the first study demonstrating that complications of liver cirrhosis, such as esophageal varices and splenomegaly, can regress after antiviral therapy in patients with HCV-related liver cirrhosis. The Korean Association for the Study of the Liver 2016-09 2016-08-30 /pmc/articles/PMC5066381/ /pubmed/27572075 http://dx.doi.org/10.3350/cmh.2015.0050 Text en Copyright © 2016 by The Korean Association for the Study of the Liver This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Soon Jae
Cho, Yoo-Kyung
Na, Soo-Young
Choi, Eun Kwang
Boo, Sun Jin
Jeong, Seung Uk
Song, Hyung Joo
Kim, Heung Up
Kim, Bong Soo
Song, Byung-Cheol
Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title_full Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title_fullStr Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title_full_unstemmed Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title_short Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
title_sort regression of esophageal varices and splenomegaly in two patients with hepatitis-c-related liver cirrhosis after interferon and ribavirin combination therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066381/
https://www.ncbi.nlm.nih.gov/pubmed/27572075
http://dx.doi.org/10.3350/cmh.2015.0050
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