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Transcranial laser stimulation improves human cerebral oxygenation
BACKGROUND AND OBJECTIVE: Transcranial laser stimulation of the brain with near‐infrared light is a novel form of non‐invasive photobiomodulation or low‐level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066697/ https://www.ncbi.nlm.nih.gov/pubmed/26817446 http://dx.doi.org/10.1002/lsm.22471 |
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author | Tian, Fenghua Hase, Snehal N. Gonzalez‐Lima, F. Liu, Hanli |
author_facet | Tian, Fenghua Hase, Snehal N. Gonzalez‐Lima, F. Liu, Hanli |
author_sort | Tian, Fenghua |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Transcranial laser stimulation of the brain with near‐infrared light is a novel form of non‐invasive photobiomodulation or low‐level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near‐infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Two separate experiments were conducted in which 1,064‐nm laser stimulation was administered at (1) the center and (2) the right side of the forehead, respectively. The laser emitted at a power of 3.4 W and in an area of 13.6 cm(2), corresponding to 0.25 W/cm(2) irradiance. Stimulation duration was 10 minutes. Nine healthy male and female human participants of any ethnic background, in an age range of 18–40 years old were included in each experiment. RESULTS: In both experiments, transcranial laser stimulation induced an increase of oxygenated hemoglobin concentration (Δ[HbO(2)]) and a decrease of deoxygenated hemoglobin concentration (Δ[Hb]) in both cerebral hemispheres. Improvements in cerebral oxygenation were indicated by a significant increase of differential hemoglobin concentration (Δ[HbD] = Δ[HbO(2)] − Δ[Hb]). These effects increased in a dose‐dependent manner over time during laser stimulation (10 minutes) and persisted after laser stimulation (6 minutes). The total hemoglobin concentration (Δ[HbT] = Δ[HbO2] + Δ[Hb]) remained nearly unchanged in most cases. CONCLUSION: Near‐infrared laser stimulation applied to the forehead can transcranially improve cerebral oxygenation in healthy humans. Lasers Surg. Med. 48:343–349, 2016. © 2016 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc. |
format | Online Article Text |
id | pubmed-5066697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50666972016-11-01 Transcranial laser stimulation improves human cerebral oxygenation Tian, Fenghua Hase, Snehal N. Gonzalez‐Lima, F. Liu, Hanli Lasers Surg Med Clinical Reports BACKGROUND AND OBJECTIVE: Transcranial laser stimulation of the brain with near‐infrared light is a novel form of non‐invasive photobiomodulation or low‐level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near‐infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Two separate experiments were conducted in which 1,064‐nm laser stimulation was administered at (1) the center and (2) the right side of the forehead, respectively. The laser emitted at a power of 3.4 W and in an area of 13.6 cm(2), corresponding to 0.25 W/cm(2) irradiance. Stimulation duration was 10 minutes. Nine healthy male and female human participants of any ethnic background, in an age range of 18–40 years old were included in each experiment. RESULTS: In both experiments, transcranial laser stimulation induced an increase of oxygenated hemoglobin concentration (Δ[HbO(2)]) and a decrease of deoxygenated hemoglobin concentration (Δ[Hb]) in both cerebral hemispheres. Improvements in cerebral oxygenation were indicated by a significant increase of differential hemoglobin concentration (Δ[HbD] = Δ[HbO(2)] − Δ[Hb]). These effects increased in a dose‐dependent manner over time during laser stimulation (10 minutes) and persisted after laser stimulation (6 minutes). The total hemoglobin concentration (Δ[HbT] = Δ[HbO2] + Δ[Hb]) remained nearly unchanged in most cases. CONCLUSION: Near‐infrared laser stimulation applied to the forehead can transcranially improve cerebral oxygenation in healthy humans. Lasers Surg. Med. 48:343–349, 2016. © 2016 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2016-01-12 2016-04 /pmc/articles/PMC5066697/ /pubmed/26817446 http://dx.doi.org/10.1002/lsm.22471 Text en © 2016 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Clinical Reports Tian, Fenghua Hase, Snehal N. Gonzalez‐Lima, F. Liu, Hanli Transcranial laser stimulation improves human cerebral oxygenation |
title | Transcranial laser stimulation improves human cerebral oxygenation |
title_full | Transcranial laser stimulation improves human cerebral oxygenation |
title_fullStr | Transcranial laser stimulation improves human cerebral oxygenation |
title_full_unstemmed | Transcranial laser stimulation improves human cerebral oxygenation |
title_short | Transcranial laser stimulation improves human cerebral oxygenation |
title_sort | transcranial laser stimulation improves human cerebral oxygenation |
topic | Clinical Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066697/ https://www.ncbi.nlm.nih.gov/pubmed/26817446 http://dx.doi.org/10.1002/lsm.22471 |
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