L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia

Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal medium spiny neurons (MSNs) and increases their excitability. However, the synaptic changes that occur in MSNs in PD, in particular those induced by chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment,...

Descripción completa

Detalles Bibliográficos
Autores principales: Suarez, Luz M, Solis, Oscar, Aguado, Carolina, Lujan, Rafael, Moratalla, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066835/
https://www.ncbi.nlm.nih.gov/pubmed/27613437
http://dx.doi.org/10.1093/cercor/bhw263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066835/
https://www.ncbi.nlm.nih.gov/pubmed/27613437
http://dx.doi.org/10.1093/cercor/bhw263

Ejemplares similares