Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

The dengue virus (DENV) nonstructural protein 5 (NS5) contains both an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain. Polymerase activity is responsible for viral RNA synthesis by a de novo initiation mechanism and represents an attractive target for antivi...

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Detalles Bibliográficos
Autores principales: Galiano, Vicente, Garcia-Valtanen, Pablo, Micol, Vicente, Encinar, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066851/
https://www.ncbi.nlm.nih.gov/pubmed/27784988
http://dx.doi.org/10.2147/DDDT.S117369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066851/
https://www.ncbi.nlm.nih.gov/pubmed/27784988
http://dx.doi.org/10.2147/DDDT.S117369

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