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Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach

The dengue virus (DENV) nonstructural protein 5 (NS5) contains both an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain. Polymerase activity is responsible for viral RNA synthesis by a de novo initiation mechanism and represents an attractive target for antivi...

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Detalles Bibliográficos
Autores principales:	Galiano, Vicente, Garcia-Valtanen, Pablo, Micol, Vicente, Encinar, José Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066851/ https://www.ncbi.nlm.nih.gov/pubmed/27784988 http://dx.doi.org/10.2147/DDDT.S117369

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