8-Oxoguanine Affects DNA Backbone Conformation in the EcoRI Recognition Site and Inhibits Its Cleavage by the Enzyme

8-oxoguanine is one of the most abundant and impactful oxidative DNA lesions. However, the reasons underlying its effects, especially those not directly explained by the altered base pairing ability, are poorly understood. We report the effect of the lesion on the action of EcoRI, a widely used rest...

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Detalles Bibliográficos
Autores principales: Hoppins, Joanna J., Gruber, David R., Miears, Heather L., Kiryutin, Alexey S., Kasymov, Rustem D., Petrova, Darya V., Endutkin, Anton V., Popov, Alexander V., Yurkovskaya, Alexandra V., Fedechkin, Stanislav O., Brockerman, Jacob A., Zharkov, Dmitry O., Smirnov, Serge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066940/
https://www.ncbi.nlm.nih.gov/pubmed/27749894
http://dx.doi.org/10.1371/journal.pone.0164424

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