miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer

Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in bre...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Shuqian, Zhang, Guihui, Dong, He, Ma, Maoqiang, Sun, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067001/
https://www.ncbi.nlm.nih.gov/pubmed/27785068
http://dx.doi.org/10.2147/OTT.S108712
_version_ 1782460580114726912
author He, Shuqian
Zhang, Guihui
Dong, He
Ma, Maoqiang
Sun, Qing
author_facet He, Shuqian
Zhang, Guihui
Dong, He
Ma, Maoqiang
Sun, Qing
author_sort He, Shuqian
collection PubMed
description Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer.
format Online
Article
Text
id pubmed-5067001
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-50670012016-10-26 miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer He, Shuqian Zhang, Guihui Dong, He Ma, Maoqiang Sun, Qing Onco Targets Ther Original Research Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer. Dove Medical Press 2016-10-11 /pmc/articles/PMC5067001/ /pubmed/27785068 http://dx.doi.org/10.2147/OTT.S108712 Text en © 2016 He et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
He, Shuqian
Zhang, Guihui
Dong, He
Ma, Maoqiang
Sun, Qing
miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title_full miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title_fullStr miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title_full_unstemmed miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title_short miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
title_sort mir-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067001/
https://www.ncbi.nlm.nih.gov/pubmed/27785068
http://dx.doi.org/10.2147/OTT.S108712
work_keys_str_mv AT heshuqian mir203facilitatestumorgrowthandmetastasisbytargetingfibroblastgrowthfactor2inbreastcancer
AT zhangguihui mir203facilitatestumorgrowthandmetastasisbytargetingfibroblastgrowthfactor2inbreastcancer
AT donghe mir203facilitatestumorgrowthandmetastasisbytargetingfibroblastgrowthfactor2inbreastcancer
AT mamaoqiang mir203facilitatestumorgrowthandmetastasisbytargetingfibroblastgrowthfactor2inbreastcancer
AT sunqing mir203facilitatestumorgrowthandmetastasisbytargetingfibroblastgrowthfactor2inbreastcancer

Ejemplares similares