Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies

Shank proteins (Shank1, Shank2, and Shank3) act as scaffolding molecules in the postsynaptic density of many excitatory neurons. Mutations in SHANK genes, in particular SHANK2 and SHANK3, lead to autism spectrum disorders (ASD) in both human and mouse models. Shank3 proteins are made of several doma...

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Detalles Bibliográficos
Autores principales: Sarowar, Tasnuva, Grabrucker, Andreas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067329/
https://www.ncbi.nlm.nih.gov/pubmed/27795858
http://dx.doi.org/10.1155/2016/8051861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067329/
https://www.ncbi.nlm.nih.gov/pubmed/27795858
http://dx.doi.org/10.1155/2016/8051861

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