CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR stimulation leads to mPTP openings is elusive. Here, we show that chronic administration of isoproterenol (ISO) persistent...

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Detalles Bibliográficos
Autores principales: Xu, Shangcheng, Wang, Pei, Zhang, Huiliang, Gong, Guohua, Gutierrez Cortes, Nicolas, Zhu, Weizhong, Yoon, Yisang, Tian, Rong, Wang, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067512/
https://www.ncbi.nlm.nih.gov/pubmed/27739424
http://dx.doi.org/10.1038/ncomms13189

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