A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological proce...

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Detalles Bibliográficos
Autores principales: Xu, Jiaxi, Mukerjee, Snigdha, Silva-Alves, Cristiane R. A., Carvalho-Galvão, Alynne, Cruz, Josiane C., Balarini, Camille M., Braga, Valdir A., Lazartigues, Eric, França-Silva, Maria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067531/
https://www.ncbi.nlm.nih.gov/pubmed/27803674
http://dx.doi.org/10.3389/fphys.2016.00469
Descripción
Sumario:ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.

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