A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological proce...

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Autores principales: Xu, Jiaxi, Mukerjee, Snigdha, Silva-Alves, Cristiane R. A., Carvalho-Galvão, Alynne, Cruz, Josiane C., Balarini, Camille M., Braga, Valdir A., Lazartigues, Eric, França-Silva, Maria S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067531/
https://www.ncbi.nlm.nih.gov/pubmed/27803674
http://dx.doi.org/10.3389/fphys.2016.00469
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author Xu, Jiaxi
Mukerjee, Snigdha
Silva-Alves, Cristiane R. A.
Carvalho-Galvão, Alynne
Cruz, Josiane C.
Balarini, Camille M.
Braga, Valdir A.
Lazartigues, Eric
França-Silva, Maria S.
author_facet Xu, Jiaxi
Mukerjee, Snigdha
Silva-Alves, Cristiane R. A.
Carvalho-Galvão, Alynne
Cruz, Josiane C.
Balarini, Camille M.
Braga, Valdir A.
Lazartigues, Eric
França-Silva, Maria S.
author_sort Xu, Jiaxi
collection PubMed
description ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.
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spelling pubmed-50675312016-11-01 A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems Xu, Jiaxi Mukerjee, Snigdha Silva-Alves, Cristiane R. A. Carvalho-Galvão, Alynne Cruz, Josiane C. Balarini, Camille M. Braga, Valdir A. Lazartigues, Eric França-Silva, Maria S. Front Physiol Physiology ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation. Frontiers Media S.A. 2016-10-18 /pmc/articles/PMC5067531/ /pubmed/27803674 http://dx.doi.org/10.3389/fphys.2016.00469 Text en Copyright © 2016 Xu, Mukerjee, Silva-Alves, Carvalho-Galvão, Cruz, Balarini, Braga, Lazartigues and França-Silva. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Jiaxi
Mukerjee, Snigdha
Silva-Alves, Cristiane R. A.
Carvalho-Galvão, Alynne
Cruz, Josiane C.
Balarini, Camille M.
Braga, Valdir A.
Lazartigues, Eric
França-Silva, Maria S.
A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title_full A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title_fullStr A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title_full_unstemmed A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title_short A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
title_sort disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067531/
https://www.ncbi.nlm.nih.gov/pubmed/27803674
http://dx.doi.org/10.3389/fphys.2016.00469
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