Cargando…

The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia

Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially re...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xu, Li, Zhi, Li, Ke, Zeng, Ya-wei, Shi, Hai-song, Xie, Wen-lan, Yang, Zhuo-ya, Lui, Simon S. Y., Cheung, Eric F. C., Leung, Ada W. S., Chan, Raymond C. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067564/
https://www.ncbi.nlm.nih.gov/pubmed/27752140
http://dx.doi.org/10.1038/srep35481
_version_ 1782460665261195264
author Li, Xu
Li, Zhi
Li, Ke
Zeng, Ya-wei
Shi, Hai-song
Xie, Wen-lan
Yang, Zhuo-ya
Lui, Simon S. Y.
Cheung, Eric F. C.
Leung, Ada W. S.
Chan, Raymond C. K.
author_facet Li, Xu
Li, Zhi
Li, Ke
Zeng, Ya-wei
Shi, Hai-song
Xie, Wen-lan
Yang, Zhuo-ya
Lui, Simon S. Y.
Cheung, Eric F. C.
Leung, Ada W. S.
Chan, Raymond C. K.
author_sort Li, Xu
collection PubMed
description Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia. Fifteen individuals with social anhedonia were recruited and received 20 sessions of training on a dual n-back task, five sessions a week. Functional imaging paradigms of the Monetary Incentive Delay (MID) and the Affective Incentive Delay (AID) tasks were administered both before and after the training to evaluate the neural transfer effects on hedonic processing ability. Enhanced brain activations related to anticipation were observed at the anterior cingulate cortex, the left dorsal striatum and the left precuneus with the AID task, and at the dorsolateral prefrontal cortex and the supramarginal gyrus with the MID task. The present findings support that WM training may improve monetary-based and affective-based hedonic processing in individuals with social anhedonia.
format Online
Article
Text
id pubmed-5067564
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50675642016-10-26 The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia Li, Xu Li, Zhi Li, Ke Zeng, Ya-wei Shi, Hai-song Xie, Wen-lan Yang, Zhuo-ya Lui, Simon S. Y. Cheung, Eric F. C. Leung, Ada W. S. Chan, Raymond C. K. Sci Rep Article Anhedonia, the diminished ability to experience pleasure, is a challenging negative symptom in patients with schizophrenia and can be observed in at-risk individuals with schizotypy. Deficits in hedonic processing have been postulated to be related to decreased motivation to engage in potentially rewarding events. It remains unclear whether non-pharmacological interventions, such as cognitive training, could improve anhedonia. The present study aimed to examine the neural mechanism for alleviating hedonic deficits with working memory (WM) training in individuals with social anhedonia. Fifteen individuals with social anhedonia were recruited and received 20 sessions of training on a dual n-back task, five sessions a week. Functional imaging paradigms of the Monetary Incentive Delay (MID) and the Affective Incentive Delay (AID) tasks were administered both before and after the training to evaluate the neural transfer effects on hedonic processing ability. Enhanced brain activations related to anticipation were observed at the anterior cingulate cortex, the left dorsal striatum and the left precuneus with the AID task, and at the dorsolateral prefrontal cortex and the supramarginal gyrus with the MID task. The present findings support that WM training may improve monetary-based and affective-based hedonic processing in individuals with social anhedonia. Nature Publishing Group 2016-10-18 /pmc/articles/PMC5067564/ /pubmed/27752140 http://dx.doi.org/10.1038/srep35481 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Xu
Li, Zhi
Li, Ke
Zeng, Ya-wei
Shi, Hai-song
Xie, Wen-lan
Yang, Zhuo-ya
Lui, Simon S. Y.
Cheung, Eric F. C.
Leung, Ada W. S.
Chan, Raymond C. K.
The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title_full The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title_fullStr The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title_full_unstemmed The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title_short The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
title_sort neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067564/
https://www.ncbi.nlm.nih.gov/pubmed/27752140
http://dx.doi.org/10.1038/srep35481
work_keys_str_mv AT lixu theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT lizhi theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT like theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT zengyawei theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT shihaisong theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT xiewenlan theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT yangzhuoya theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT luisimonsy theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT cheungericfc theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT leungadaws theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT chanraymondck theneuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT lixu neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT lizhi neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT like neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT zengyawei neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT shihaisong neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT xiewenlan neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT yangzhuoya neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT luisimonsy neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT cheungericfc neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT leungadaws neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia
AT chanraymondck neuraltransfereffectofworkingmemorytrainingtoenhancehedonicprocessinginindividualswithsocialanhedonia