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Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

STAT5 is an essential transcription factor in hematopoiesis, which is activated through tyrosine phosphorylation in response to cytokine stimulation. Constitutive activation of STAT5 is a hallmark of myeloid and lymphoblastic leukemia. Using homology modeling and molecular dynamics simulations, a mo...

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Detalles Bibliográficos
Autores principales:	Fahrenkamp, Dirk, Li, Jinyu, Ernst, Sabrina, Schmitz-Van de Leur, Hildegard, Chatain, Nicolas, Küster, Andrea, Koschmieder, Steffen, Lüscher, Bernhard, Rossetti, Giulia, Müller-Newen, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067585/ https://www.ncbi.nlm.nih.gov/pubmed/27752093 http://dx.doi.org/10.1038/srep35454

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