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Nutritional Predictors of Mortality in Long Term Hemodialysis Patients
Serum albumin had been noted to be a predictor of mortality in hemodialysis (HD) patients. Normalized protein catabolic rate (nPCR) less than 0.8 or greater than 1.4 g/kg/d was also associated with greater mortality. There was no previous study to show the effectiveness of combination of serum album...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067672/ https://www.ncbi.nlm.nih.gov/pubmed/27752119 http://dx.doi.org/10.1038/srep35639 |
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author | Weng, Cheng-Hao Hu, Ching-Chih Yen, Tzung-Hai Hsu, Ching-Wei Huang, Wen-Hung |
author_facet | Weng, Cheng-Hao Hu, Ching-Chih Yen, Tzung-Hai Hsu, Ching-Wei Huang, Wen-Hung |
author_sort | Weng, Cheng-Hao |
collection | PubMed |
description | Serum albumin had been noted to be a predictor of mortality in hemodialysis (HD) patients. Normalized protein catabolic rate (nPCR) less than 0.8 or greater than 1.4 g/kg/d was also associated with greater mortality. There was no previous study to show the effectiveness of combination of serum albumin and nPCR to predict the mortality in chronic HD patients. Eight hundred and sixty-six patients were divided into 4 groups according to their nPCR and serum albumin levels. Biochemical, and hematological parameters were recorded. The associations between groups, variables mentioned above and mortality were analyzed. Multivariate Cox regression analysis showed that age, diabetes mellitus, fistula as blood access, nPCR <1.2 g/kg/day combined with albumin <4 (Group A), nPCR ≧ 1.2 g/kg/day combined with albumin <4 g/dL (Group B) (nPCR ≧ 1.2 g/kg/day combined with Albumin ≧ 4 g/dL as reference group), non-anuria, hemoglobin, creatinine, and log (high sensitivity C reactive protein) were correlated with 36 months mortality. Group A and group B patients had higher 36 months cardiovascular (CV) and infection related mortality rates as compared with group D patients. In conclusion, Group A and Group B patients had significantly higher rate of all-cause, CV and infection related mortality. |
format | Online Article Text |
id | pubmed-5067672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50676722016-10-26 Nutritional Predictors of Mortality in Long Term Hemodialysis Patients Weng, Cheng-Hao Hu, Ching-Chih Yen, Tzung-Hai Hsu, Ching-Wei Huang, Wen-Hung Sci Rep Article Serum albumin had been noted to be a predictor of mortality in hemodialysis (HD) patients. Normalized protein catabolic rate (nPCR) less than 0.8 or greater than 1.4 g/kg/d was also associated with greater mortality. There was no previous study to show the effectiveness of combination of serum albumin and nPCR to predict the mortality in chronic HD patients. Eight hundred and sixty-six patients were divided into 4 groups according to their nPCR and serum albumin levels. Biochemical, and hematological parameters were recorded. The associations between groups, variables mentioned above and mortality were analyzed. Multivariate Cox regression analysis showed that age, diabetes mellitus, fistula as blood access, nPCR <1.2 g/kg/day combined with albumin <4 (Group A), nPCR ≧ 1.2 g/kg/day combined with albumin <4 g/dL (Group B) (nPCR ≧ 1.2 g/kg/day combined with Albumin ≧ 4 g/dL as reference group), non-anuria, hemoglobin, creatinine, and log (high sensitivity C reactive protein) were correlated with 36 months mortality. Group A and group B patients had higher 36 months cardiovascular (CV) and infection related mortality rates as compared with group D patients. In conclusion, Group A and Group B patients had significantly higher rate of all-cause, CV and infection related mortality. Nature Publishing Group 2016-10-18 /pmc/articles/PMC5067672/ /pubmed/27752119 http://dx.doi.org/10.1038/srep35639 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Weng, Cheng-Hao Hu, Ching-Chih Yen, Tzung-Hai Hsu, Ching-Wei Huang, Wen-Hung Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title | Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title_full | Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title_fullStr | Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title_full_unstemmed | Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title_short | Nutritional Predictors of Mortality in Long Term Hemodialysis Patients |
title_sort | nutritional predictors of mortality in long term hemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067672/ https://www.ncbi.nlm.nih.gov/pubmed/27752119 http://dx.doi.org/10.1038/srep35639 |
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