The expanding role of Tax in transcription

The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactiv...

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Detalles Bibliográficos
Autores principales: de la Fuente, Cynthia, Kashanchi, Fatah
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC506788/
https://www.ncbi.nlm.nih.gov/pubmed/15285790
http://dx.doi.org/10.1186/1742-4690-1-19
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author de la Fuente, Cynthia
Kashanchi, Fatah
author_facet de la Fuente, Cynthia
Kashanchi, Fatah
author_sort de la Fuente, Cynthia
collection PubMed
description The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repeats through CREB1 and not other bZIP proteins. The additional transactivation of Tax-responsive promoters subsequent to initiation is also presented. This result highlights a potentially novel role of Tax following TBP recruitment (i.e. initiation) and may expand the mechanism of Tax transactivation in promoter clearance and transcriptional elongation.
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spelling pubmed-5067882004-08-08 The expanding role of Tax in transcription de la Fuente, Cynthia Kashanchi, Fatah Retrovirology Commentary The viral transactivator of HTLV-I, Tax, has long been shown to target the earliest steps of transcription by forming quaternary complexes with sequence specific transcription factors and histone-modifying enzymes in the LTR of HTLV-I. However, a new study suggests that Tax preferentially transactivates the 21-bp repeats through CREB1 and not other bZIP proteins. The additional transactivation of Tax-responsive promoters subsequent to initiation is also presented. This result highlights a potentially novel role of Tax following TBP recruitment (i.e. initiation) and may expand the mechanism of Tax transactivation in promoter clearance and transcriptional elongation. BioMed Central 2004-07-30 /pmc/articles/PMC506788/ /pubmed/15285790 http://dx.doi.org/10.1186/1742-4690-1-19 Text en Copyright © 2004 de la Fuente and Kashanchi; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
de la Fuente, Cynthia
Kashanchi, Fatah
The expanding role of Tax in transcription
title The expanding role of Tax in transcription
title_full The expanding role of Tax in transcription
title_fullStr The expanding role of Tax in transcription
title_full_unstemmed The expanding role of Tax in transcription
title_short The expanding role of Tax in transcription
title_sort expanding role of tax in transcription
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC506788/
https://www.ncbi.nlm.nih.gov/pubmed/15285790
http://dx.doi.org/10.1186/1742-4690-1-19
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