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Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients

BACKGROUND: Calcitonin gene-related peptide (CGRP) is a 37-amino-acid vasodilatory neuropeptide that binds to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CLR). Clinical and preclinical evidence suggests that CGRP is associated with hip and knee joint pain...

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Detalles Bibliográficos
Autores principales:	Minatani, Atsushi, Uchida, Kentaro, Inoue, Gen, Takano, Shotaro, Aikawa, Jun, Miyagi, Masayuki, Fujimaki, Hisako, Iwase, Dai, Onuma, Kenji, Matsumoto, Toshihide, Takaso, Masashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067902/ https://www.ncbi.nlm.nih.gov/pubmed/27751171 http://dx.doi.org/10.1186/s13018-016-0460-4

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