LRP5 Signaling in Osteosarcomagenesis: a Cautionary Tale of Translation from Cell Lines to Tumors()()

Previous reports document expression of low-density lipoprotein receptor-related protein 5 (LRP5) in osteosarcoma (OS) tissue. Expression of this Wnt receptor correlated with metastatic disease and poor disease-free survival. Forced expression of dominant-negative LRP5 (dnLRP5), which lacks the memb...

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Detalles Bibliográficos
Autores principales: Horne, Logan, Avilucea, Frank R., Jin, Huifeng, Barrott, Jared J., Smith-Fry, Kyllie, Wang, Yanliang, Hoang, Bang H., Jones, Kevin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067932/
https://www.ncbi.nlm.nih.gov/pubmed/27751348
http://dx.doi.org/10.1016/j.tranon.2016.08.010

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