Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes

Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) are associated with various cancers including myelodysplastic syndrome (MDS). Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3′ tail of ATG7. This results in altered...

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Detalles Bibliográficos
Autores principales: Ali, Abdullah M., Raza, Azra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068173/
https://www.ncbi.nlm.nih.gov/pubmed/27857975
http://dx.doi.org/10.1080/23723556.2016.1212686
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author Ali, Abdullah M.
Raza, Azra
author_facet Ali, Abdullah M.
Raza, Azra
author_sort Ali, Abdullah M.
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description Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) are associated with various cancers including myelodysplastic syndrome (MDS). Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3′ tail of ATG7. This results in altered mitochondrial function, increased reactive oxygen species production, and genomic instability.
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spelling pubmed-50681732017-07-26 Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes Ali, Abdullah M. Raza, Azra Mol Cell Oncol Author's View Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) are associated with various cancers including myelodysplastic syndrome (MDS). Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3′ tail of ATG7. This results in altered mitochondrial function, increased reactive oxygen species production, and genomic instability. Taylor & Francis 2016-07-26 /pmc/articles/PMC5068173/ /pubmed/27857975 http://dx.doi.org/10.1080/23723556.2016.1212686 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Ali, Abdullah M.
Raza, Azra
Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title_full Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title_fullStr Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title_full_unstemmed Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title_short Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
title_sort two different “tales” of atg7: clinical relevance to myelodysplastic syndromes
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068173/
https://www.ncbi.nlm.nih.gov/pubmed/27857975
http://dx.doi.org/10.1080/23723556.2016.1212686
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