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Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a
Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response. Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen-presenting Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high...
Autores principales: | Cheung, Ka Lun, Jarrett, Rachael, Subramaniam, Sumithra, Salimi, Maryam, Gutowska-Owsiak, Danuta, Chen, Yi-Ling, Hardman, Clare, Xue, Luzheng, Cerundolo, Vincenzo, Ogg, Graham |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068234/ https://www.ncbi.nlm.nih.gov/pubmed/27670592 http://dx.doi.org/10.1084/jem.20160258 |
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