UNG protects B cells from AID-induced telomere loss

Activation-induced deaminase (AID) initiates antibody gene diversification by creating G:U mismatches in the immunoglobulin loci. However, AID also deaminates nonimmunoglobulin genes, and failure to faithfully repair these off-target lesions can cause B cell lymphoma. In this study, we identify a me...

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Detalles Bibliográficos
Autores principales: Cortizas, Elena M., Zahn, Astrid, Safavi, Shiva, Reed, Joseph A., Vega, Francisco, Di Noia, Javier M., Verdun, Ramiro E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068241/
https://www.ncbi.nlm.nih.gov/pubmed/27697833
http://dx.doi.org/10.1084/jem.20160635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068241/
https://www.ncbi.nlm.nih.gov/pubmed/27697833
http://dx.doi.org/10.1084/jem.20160635

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