Cargando…

Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis

We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley...

Descripción completa

Detalles Bibliográficos
Autores principales: Wickramasinghe, A, Tulloch, A D, Hayes, R D, Chang, C-K, Broadbent, M, Di Forti, M, Murray, R M, Iyegbe, C, Stewart, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068593/
https://www.ncbi.nlm.nih.gov/pubmed/26670283
http://dx.doi.org/10.1038/tp.2015.198
_version_ 1782460805348851712
author Wickramasinghe, A
Tulloch, A D
Hayes, R D
Chang, C-K
Broadbent, M
Di Forti, M
Murray, R M
Iyegbe, C
Stewart, R
author_facet Wickramasinghe, A
Tulloch, A D
Hayes, R D
Chang, C-K
Broadbent, M
Di Forti, M
Murray, R M
Iyegbe, C
Stewart, R
author_sort Wickramasinghe, A
collection PubMed
description We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome.
format Online
Article
Text
id pubmed-5068593
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50685932016-10-20 Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis Wickramasinghe, A Tulloch, A D Hayes, R D Chang, C-K Broadbent, M Di Forti, M Murray, R M Iyegbe, C Stewart, R Transl Psychiatry Original Article We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome. Nature Publishing Group 2015-12 2015-12-15 /pmc/articles/PMC5068593/ /pubmed/26670283 http://dx.doi.org/10.1038/tp.2015.198 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
Wickramasinghe, A
Tulloch, A D
Hayes, R D
Chang, C-K
Broadbent, M
Di Forti, M
Murray, R M
Iyegbe, C
Stewart, R
Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title_full Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title_fullStr Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title_full_unstemmed Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title_short Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
title_sort associations between the schizophrenia susceptibility gene znf804a and clinical outcomes in psychosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068593/
https://www.ncbi.nlm.nih.gov/pubmed/26670283
http://dx.doi.org/10.1038/tp.2015.198
work_keys_str_mv AT wickramasinghea associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT tullochad associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT hayesrd associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT changck associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT broadbentm associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT difortim associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT murrayrm associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT iyegbec associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis
AT stewartr associationsbetweentheschizophreniasusceptibilitygeneznf804aandclinicaloutcomesinpsychosis