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Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis
We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068593/ https://www.ncbi.nlm.nih.gov/pubmed/26670283 http://dx.doi.org/10.1038/tp.2015.198 |
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author | Wickramasinghe, A Tulloch, A D Hayes, R D Chang, C-K Broadbent, M Di Forti, M Murray, R M Iyegbe, C Stewart, R |
author_facet | Wickramasinghe, A Tulloch, A D Hayes, R D Chang, C-K Broadbent, M Di Forti, M Murray, R M Iyegbe, C Stewart, R |
author_sort | Wickramasinghe, A |
collection | PubMed |
description | We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome. |
format | Online Article Text |
id | pubmed-5068593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50685932016-10-20 Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis Wickramasinghe, A Tulloch, A D Hayes, R D Chang, C-K Broadbent, M Di Forti, M Murray, R M Iyegbe, C Stewart, R Transl Psychiatry Original Article We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust—a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20–29 or F30–33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome. Nature Publishing Group 2015-12 2015-12-15 /pmc/articles/PMC5068593/ /pubmed/26670283 http://dx.doi.org/10.1038/tp.2015.198 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article Wickramasinghe, A Tulloch, A D Hayes, R D Chang, C-K Broadbent, M Di Forti, M Murray, R M Iyegbe, C Stewart, R Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title | Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title_full | Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title_fullStr | Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title_full_unstemmed | Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title_short | Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis |
title_sort | associations between the schizophrenia susceptibility gene znf804a and clinical outcomes in psychosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068593/ https://www.ncbi.nlm.nih.gov/pubmed/26670283 http://dx.doi.org/10.1038/tp.2015.198 |
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