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Bmi1 Loss in the Organ of Corti Results in p16(ink4a) Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro

The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age. The polycomb gene B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) promotes proliferation and cell cycle progression...

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Detalles Bibliográficos
Autores principales:	Bassiouni, Mohamed, Dos Santos, Aurélie, Avci, Hasan X., Löwenheim, Hubert, Müller, Marcus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068820/ https://www.ncbi.nlm.nih.gov/pubmed/27755610 http://dx.doi.org/10.1371/journal.pone.0164579

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