CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation

Mutations in SCN1A, the gene encoding the α subunit of Nav1.1 channel, can cause epilepsies with wide ranges of clinical phenotypes, which are associated with the contrasting effects of channel loss-of-function or gain-of-function. In this project, CRISPR/Cas9- and TALEN-mediated genome-editing tech...

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Detalles Bibliográficos
Autores principales: Liu, J, Gao, C, Chen, W, Ma, W, Li, X, Shi, Y, Zhang, H, Zhang, L, Long, Y, Xu, H, Guo, X, Deng, S, Yan, X, Yu, D, Pan, G, Chen, Y, Lai, L, Liao, W, Li, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068877/
https://www.ncbi.nlm.nih.gov/pubmed/26731440
http://dx.doi.org/10.1038/tp.2015.203

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