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Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator
PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relation...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069301/ https://www.ncbi.nlm.nih.gov/pubmed/27614458 http://dx.doi.org/10.1007/s40618-016-0544-3 |
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author | Menzel, J. Di Giuseppe, R. Biemann, R. Aleksandrova, K. Kuxhaus, O. Wittenbecher, C. Fritsche, A. Schulze, M. B. Isermann, B. Boeing, H. Weikert, C. |
author_facet | Menzel, J. Di Giuseppe, R. Biemann, R. Aleksandrova, K. Kuxhaus, O. Wittenbecher, C. Fritsche, A. Schulze, M. B. Isermann, B. Boeing, H. Weikert, C. |
author_sort | Menzel, J. |
collection | PubMed |
description | PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator. METHODS: Data from the German population-based EPIC-Potsdam cohort comprising 637 women were analyzed. Multivariable-adjusted ANCOVA including age, BMI, waist circumference, smoking status, education, physical activity, adiponectin or omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BUA levels. A mediation analysis assessed the mediating effect of OPG on the association of BUA and omentin-1 levels. RESULTS: Peri-/premenopausal women had higher BUA levels (112.5 ± 10.1 dB/MHz), compared to postmenopausal women (106.3 ± 10.0 dB/MHz). In peri-/premenopausal women neither adiponectin nor omentin-1 was significantly associated with BUA. In postmenopausal women, adiponectin was not associated with BUA, but 10 % increase in the omentin-1 concentration was significantly associated with 0.44 dB/MHz lower BUA levels (p = 0.01). Omentin-1 was positively associated with OPG (p = 0.02); however, OPG was not significantly related to BUA (p = 0.62). CONCLUSION: Our study provides evidence for an inverse association between circulating omentin-1 and BUA levels in postmenopausal women. However, the present findings do not support a mediating effect of OPG in the adipose tissue–bone pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40618-016-0544-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5069301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-50693012016-11-02 Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator Menzel, J. Di Giuseppe, R. Biemann, R. Aleksandrova, K. Kuxhaus, O. Wittenbecher, C. Fritsche, A. Schulze, M. B. Isermann, B. Boeing, H. Weikert, C. J Endocrinol Invest Original Article PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator. METHODS: Data from the German population-based EPIC-Potsdam cohort comprising 637 women were analyzed. Multivariable-adjusted ANCOVA including age, BMI, waist circumference, smoking status, education, physical activity, adiponectin or omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BUA levels. A mediation analysis assessed the mediating effect of OPG on the association of BUA and omentin-1 levels. RESULTS: Peri-/premenopausal women had higher BUA levels (112.5 ± 10.1 dB/MHz), compared to postmenopausal women (106.3 ± 10.0 dB/MHz). In peri-/premenopausal women neither adiponectin nor omentin-1 was significantly associated with BUA. In postmenopausal women, adiponectin was not associated with BUA, but 10 % increase in the omentin-1 concentration was significantly associated with 0.44 dB/MHz lower BUA levels (p = 0.01). Omentin-1 was positively associated with OPG (p = 0.02); however, OPG was not significantly related to BUA (p = 0.62). CONCLUSION: Our study provides evidence for an inverse association between circulating omentin-1 and BUA levels in postmenopausal women. However, the present findings do not support a mediating effect of OPG in the adipose tissue–bone pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40618-016-0544-3) contains supplementary material, which is available to authorized users. Springer International Publishing 2016-09-10 2016 /pmc/articles/PMC5069301/ /pubmed/27614458 http://dx.doi.org/10.1007/s40618-016-0544-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Menzel, J. Di Giuseppe, R. Biemann, R. Aleksandrova, K. Kuxhaus, O. Wittenbecher, C. Fritsche, A. Schulze, M. B. Isermann, B. Boeing, H. Weikert, C. Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title | Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title_full | Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title_fullStr | Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title_full_unstemmed | Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title_short | Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
title_sort | association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069301/ https://www.ncbi.nlm.nih.gov/pubmed/27614458 http://dx.doi.org/10.1007/s40618-016-0544-3 |
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