Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

Objective. To evaluate thermosensitive, biodegradable pentablock copolymers (PTSgel) for sustained release and integrity of a therapeutic protein when injected subcutaneously. Materials and Methods. Five PTSgels with PEG-PCL-PLA-PCL-PEG block arrangements were synthesized. In vitro release of IgG fr...

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Detalles Bibliográficos
Autores principales: Schaefer, Elizabeth, Abbaraju, Santhi, Walsh, Mary, Newman, Donna, Salmon, Jacklyn, Amin, Rasidul, Weiss, Sidney, Grau, Ulrich, Velagaleti, Poonam, Gilger, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069382/
https://www.ncbi.nlm.nih.gov/pubmed/27800184
http://dx.doi.org/10.1155/2016/2407459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069382/
https://www.ncbi.nlm.nih.gov/pubmed/27800184
http://dx.doi.org/10.1155/2016/2407459

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