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β‐catenin‐driven binary cell fate decisions in animal development
The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley & Sons, Inc.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069452/ https://www.ncbi.nlm.nih.gov/pubmed/26952169 http://dx.doi.org/10.1002/wdev.228 |
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author | Bertrand, Vincent |
author_facet | Bertrand, Vincent |
author_sort | Bertrand, Vincent |
collection | PubMed |
description | The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode Caenorhabditis elegans, the annelid Platynereis, and the ascidian Ciona. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β‐catenin levels between daughter cells. β‐Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. WIREs Dev Biol 2016, 5:377–388. doi: 10.1002/wdev.228 For further resources related to this article, please visit the WIREs website. |
format | Online Article Text |
id | pubmed-5069452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50694522016-11-01 β‐catenin‐driven binary cell fate decisions in animal development Bertrand, Vincent Wiley Interdiscip Rev Dev Biol Advanced Reviews The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode Caenorhabditis elegans, the annelid Platynereis, and the ascidian Ciona. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β‐catenin levels between daughter cells. β‐Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. WIREs Dev Biol 2016, 5:377–388. doi: 10.1002/wdev.228 For further resources related to this article, please visit the WIREs website. John Wiley & Sons, Inc. 2016-03-07 2016 /pmc/articles/PMC5069452/ /pubmed/26952169 http://dx.doi.org/10.1002/wdev.228 Text en © 2016 The Authors. WIREs Developmental Biology published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Advanced Reviews Bertrand, Vincent β‐catenin‐driven binary cell fate decisions in animal development |
title | β‐catenin‐driven binary cell fate decisions in animal development |
title_full | β‐catenin‐driven binary cell fate decisions in animal development |
title_fullStr | β‐catenin‐driven binary cell fate decisions in animal development |
title_full_unstemmed | β‐catenin‐driven binary cell fate decisions in animal development |
title_short | β‐catenin‐driven binary cell fate decisions in animal development |
title_sort | β‐catenin‐driven binary cell fate decisions in animal development |
topic | Advanced Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069452/ https://www.ncbi.nlm.nih.gov/pubmed/26952169 http://dx.doi.org/10.1002/wdev.228 |
work_keys_str_mv | AT bertrandvincent bcatenindrivenbinarycellfatedecisionsinanimaldevelopment |