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β‐catenin‐driven binary cell fate decisions in animal development

The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong t...

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Autor principal: Bertrand, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069452/
https://www.ncbi.nlm.nih.gov/pubmed/26952169
http://dx.doi.org/10.1002/wdev.228
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author Bertrand, Vincent
author_facet Bertrand, Vincent
author_sort Bertrand, Vincent
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description The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode Caenorhabditis elegans, the annelid Platynereis, and the ascidian Ciona. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β‐catenin levels between daughter cells. β‐Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. WIREs Dev Biol 2016, 5:377–388. doi: 10.1002/wdev.228 For further resources related to this article, please visit the WIREs website.
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spelling pubmed-50694522016-11-01 β‐catenin‐driven binary cell fate decisions in animal development Bertrand, Vincent Wiley Interdiscip Rev Dev Biol Advanced Reviews The Wnt/β‐catenin pathway plays key roles during animal development. In several species, β‐catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode Caenorhabditis elegans, the annelid Platynereis, and the ascidian Ciona. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β‐catenin levels between daughter cells. β‐Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. WIREs Dev Biol 2016, 5:377–388. doi: 10.1002/wdev.228 For further resources related to this article, please visit the WIREs website. John Wiley & Sons, Inc. 2016-03-07 2016 /pmc/articles/PMC5069452/ /pubmed/26952169 http://dx.doi.org/10.1002/wdev.228 Text en © 2016 The Authors. WIREs Developmental Biology published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Advanced Reviews
Bertrand, Vincent
β‐catenin‐driven binary cell fate decisions in animal development
title β‐catenin‐driven binary cell fate decisions in animal development
title_full β‐catenin‐driven binary cell fate decisions in animal development
title_fullStr β‐catenin‐driven binary cell fate decisions in animal development
title_full_unstemmed β‐catenin‐driven binary cell fate decisions in animal development
title_short β‐catenin‐driven binary cell fate decisions in animal development
title_sort β‐catenin‐driven binary cell fate decisions in animal development
topic Advanced Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069452/
https://www.ncbi.nlm.nih.gov/pubmed/26952169
http://dx.doi.org/10.1002/wdev.228
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