Cargando…
Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis
Dynamic synapses facilitate activity‐dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the mechanisms governing dynamic synapses in adult brain are still largely unknown. Here, we demonstrate that in the cortex of adult amyloid precu...
Autores principales: | Zou, Chengyu, Crux, Sophie, Marinesco, Stephane, Montagna, Elena, Sgobio, Carmelo, Shi, Yuan, Shi, Song, Zhu, Kaichuan, Dorostkar, Mario M, Müller, Ulrike C, Herms, Jochen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069548/ https://www.ncbi.nlm.nih.gov/pubmed/27572463 http://dx.doi.org/10.15252/embj.201694085 |
Ejemplares similares
-
Tcf4 regulates dendritic spine density and morphology in the adult brain
por: Crux, Sophie, et al.
Publicado: (2018) -
The Role of APP in Structural Spine Plasticity
por: Montagna, Elena, et al.
Publicado: (2017) -
Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease
por: Zou, Chengyu, et al.
Publicado: (2015) -
Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease
por: Zou, Chengyu, et al.
Publicado: (2016) -
Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities
por: Dorostkar, Mario M., et al.
Publicado: (2015)