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Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed t...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069563/ https://www.ncbi.nlm.nih.gov/pubmed/26833743 http://dx.doi.org/10.1111/apa.13350 |
| _version_ | 1782460960021151744 |
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| author | Hellström, Ann Ley, David Hansen‐Pupp, Ingrid Hallberg, Boubou Löfqvist, Chatarina van Marter, Linda van Weissenbruch, Mirjam Ramenghi, Luca A. Beardsall, Kathryn Dunger, David Hård, Anna‐Lena Smith, Lois E. H. |
| author_facet | Hellström, Ann Ley, David Hansen‐Pupp, Ingrid Hallberg, Boubou Löfqvist, Chatarina van Marter, Linda van Weissenbruch, Mirjam Ramenghi, Luca A. Beardsall, Kathryn Dunger, David Hård, Anna‐Lena Smith, Lois E. H. |
| author_sort | Hellström, Ann |
| collection | PubMed |
| description | Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed the role of IGF‐1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF‐1 deficiency in preterm morbidities. CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF‐1 replacement in very preterm infants. |
| format | Online Article Text |
| id | pubmed-5069563 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50695632016-11-01 Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development Hellström, Ann Ley, David Hansen‐Pupp, Ingrid Hallberg, Boubou Löfqvist, Chatarina van Marter, Linda van Weissenbruch, Mirjam Ramenghi, Luca A. Beardsall, Kathryn Dunger, David Hård, Anna‐Lena Smith, Lois E. H. Acta Paediatr Review Articles Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed the role of IGF‐1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF‐1 deficiency in preterm morbidities. CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF‐1 replacement in very preterm infants. John Wiley and Sons Inc. 2016-03-08 2016-06 /pmc/articles/PMC5069563/ /pubmed/26833743 http://dx.doi.org/10.1111/apa.13350 Text en ©2016 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Review Articles Hellström, Ann Ley, David Hansen‐Pupp, Ingrid Hallberg, Boubou Löfqvist, Chatarina van Marter, Linda van Weissenbruch, Mirjam Ramenghi, Luca A. Beardsall, Kathryn Dunger, David Hård, Anna‐Lena Smith, Lois E. H. Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title | Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title_full | Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title_fullStr | Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title_full_unstemmed | Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title_short | Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| title_sort | insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development |
| topic | Review Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069563/ https://www.ncbi.nlm.nih.gov/pubmed/26833743 http://dx.doi.org/10.1111/apa.13350 |
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