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Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data
The aim of this study was to improve the accuracy and precision of perfusion fraction and blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis of flow‐compensated and non‐flow‐compensated motion‐encoded MRI data. A double diffusion encoding sequenc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069652/ https://www.ncbi.nlm.nih.gov/pubmed/26952166 http://dx.doi.org/10.1002/nbm.3505 |
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author | Ahlgren, André Knutsson, Linda Wirestam, Ronnie Nilsson, Markus Ståhlberg, Freddy Topgaard, Daniel Lasič, Samo |
author_facet | Ahlgren, André Knutsson, Linda Wirestam, Ronnie Nilsson, Markus Ståhlberg, Freddy Topgaard, Daniel Lasič, Samo |
author_sort | Ahlgren, André |
collection | PubMed |
description | The aim of this study was to improve the accuracy and precision of perfusion fraction and blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis of flow‐compensated and non‐flow‐compensated motion‐encoded MRI data. A double diffusion encoding sequence capable of switching between flow‐compensated and non‐flow‐compensated encoding modes was implemented. In vivo brain data were collected in eight healthy volunteers and processed using the joint analysis. Simulations were used to compare the performance of the proposed analysis method with conventional IVIM analysis. With flow compensation, strong rephasing was observed for the in vivo data, approximately cancelling the IVIM effect. The joint analysis yielded physiologically reasonable perfusion fraction maps. Estimated perfusion fractions were 2.43 ± 0.81% in gray matter, 1.81 ± 0.90% in deep gray matter, and 1.64 ± 0.72% in white matter (mean ± SD, n = 8). Simulations showed improved accuracy and precision when using joint analysis of flow‐compensated and non‐flow‐compensated data, compared with conventional IVIM analysis. Double diffusion encoding with flow compensation was feasible for in vivo imaging of the perfusion fraction in the brain. The strong rephasing implied that blood flowing through the cerebral microvascular system was closer to the ballistic limit than the diffusive limit. © 2016 The Authors NMR in Biomedicine published by John Wiley & Sons Ltd. |
format | Online Article Text |
id | pubmed-5069652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50696522016-11-02 Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data Ahlgren, André Knutsson, Linda Wirestam, Ronnie Nilsson, Markus Ståhlberg, Freddy Topgaard, Daniel Lasič, Samo NMR Biomed Research Articles The aim of this study was to improve the accuracy and precision of perfusion fraction and blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis of flow‐compensated and non‐flow‐compensated motion‐encoded MRI data. A double diffusion encoding sequence capable of switching between flow‐compensated and non‐flow‐compensated encoding modes was implemented. In vivo brain data were collected in eight healthy volunteers and processed using the joint analysis. Simulations were used to compare the performance of the proposed analysis method with conventional IVIM analysis. With flow compensation, strong rephasing was observed for the in vivo data, approximately cancelling the IVIM effect. The joint analysis yielded physiologically reasonable perfusion fraction maps. Estimated perfusion fractions were 2.43 ± 0.81% in gray matter, 1.81 ± 0.90% in deep gray matter, and 1.64 ± 0.72% in white matter (mean ± SD, n = 8). Simulations showed improved accuracy and precision when using joint analysis of flow‐compensated and non‐flow‐compensated data, compared with conventional IVIM analysis. Double diffusion encoding with flow compensation was feasible for in vivo imaging of the perfusion fraction in the brain. The strong rephasing implied that blood flowing through the cerebral microvascular system was closer to the ballistic limit than the diffusive limit. © 2016 The Authors NMR in Biomedicine published by John Wiley & Sons Ltd. John Wiley and Sons Inc. 2016-03-08 2016-05 /pmc/articles/PMC5069652/ /pubmed/26952166 http://dx.doi.org/10.1002/nbm.3505 Text en © 2016 The Authors NMR in Biomedicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Ahlgren, André Knutsson, Linda Wirestam, Ronnie Nilsson, Markus Ståhlberg, Freddy Topgaard, Daniel Lasič, Samo Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title | Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title_full | Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title_fullStr | Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title_full_unstemmed | Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title_short | Quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (IVIM) data |
title_sort | quantification of microcirculatory parameters by joint analysis of flow‐compensated and non‐flow‐compensated intravoxel incoherent motion (ivim) data |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069652/ https://www.ncbi.nlm.nih.gov/pubmed/26952166 http://dx.doi.org/10.1002/nbm.3505 |
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