Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways

BACKGROUND: Previous studies have reported that eEF-2 kinase is associated with tumour cell sensitivity to certain therapies. In the present study, we investigated the relationship between eEF-2 kinase and lapatinib, a dual inhibitor of EGFR and HER-2, in nasopharyngeal carcinoma (NPC) cells. METHOD...

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Detalles Bibliográficos
Autores principales: Liu, Lin, Huang, PeiYu, Wang, ZhiHui, Chen, Nan, Tang, Con, Lin, Zhong, Peng, PeiJian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069787/
https://www.ncbi.nlm.nih.gov/pubmed/27756261
http://dx.doi.org/10.1186/s12885-016-2853-5

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