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Lentivirus-mediated short hairpin RNA interference targeting TNF-alpha in macrophages inhibits particle-induced inflammation and osteolysis in vitro and in vivo

BACKGROUND: Aseptic loosening is a significant impediment to joint implant longevity. Prosthetic wear particles are postulated to play a central role in the onset and progression of periprosthetic osteolysis, leading to aseptic loosening of the prosthesis. METHODS: We investigated the inhibitory eff...

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Detalles Bibliográficos
Autores principales:	Qin, Chu-qiang, Huang, Dong-sheng, Zhang, Chi, Song, Bin, Huang, Jian-bin, Ding, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069821/ https://www.ncbi.nlm.nih.gov/pubmed/27756280 http://dx.doi.org/10.1186/s12891-016-1290-6

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