Synthesis of nanoparticle CT contrast agents: in vitro and in vivo studies

Water-soluble and biocompatible D-glucuronic acid coated Na(2)WO(4) and BaCO(3) nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated Na(2)WO(4) and...

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Detalles Bibliográficos
Autores principales: Kim, Sung June, Xu, Wenlong, Ahmad, Md Wasi, Baeck, Jong Su, Chang, Yongmin, Bae, Ji Eun, Chae, Kwon Seok, Kim, Tae Jeong, Park, Ji Ae, Lee, Gang Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070024/
https://www.ncbi.nlm.nih.gov/pubmed/27877838
http://dx.doi.org/10.1088/1468-6996/16/5/055003
Descripción
Sumario:Water-soluble and biocompatible D-glucuronic acid coated Na(2)WO(4) and BaCO(3) nanoparticles were synthesized for the first time to be used as x-ray computed tomography (CT) contrast agents. Their average particle diameters were 3.2 ± 0.1 and 2.8 ± 0.1 nm for D-glucuronic acid coated Na(2)WO(4) and BaCO(3) nanoparticles, respectively. All the nanoparticles exhibited a strong x-ray attenuation. In vivo CT images were obtained after intravenous injection of an aqueous sample suspension of D-glucuronic acid coated Na(2)WO(4) nanoparticles, and positive contrast enhancements in the kidney were clearly shown. These findings indicate that the nanoparticles reported in this study may be promising CT contrast agents.

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