Cargando…

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

The evidence for a protective role of physical activity on the risk and progression of Alzheimer's disease (AD) has been growing in the last years. Here we studied the influence of a prolonged physical and cognitive stimulation on neurodegeneration, with special emphasis on hippocampal neuron l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hüttenrauch, M, Brauß, A, Kurdakova, A, Borgers, H, Klinker, F, Liebetanz, D, Salinas-Riester, G, Wiltfang, J, Klafki, H W, Wirths, O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070068/ https://www.ncbi.nlm.nih.gov/pubmed/27138799 http://dx.doi.org/10.1038/tp.2016.65

Ejemplares similares

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia
por: Hüttenrauch, Melanie, et al.
Publicado: (2018)

Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice
por: Hüttenrauch, Melanie, et al.
Publicado: (2016)

A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease
por: Shahpasand-Kroner, Hedieh, et al.
Publicado: (2018)

Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer’s Disease
por: Gerberding, Anna-Lina, et al.
Publicado: (2019)

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer’s disease
por: Zampar, S., et al.
Publicado: (2020)

Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing
por: Bouter, Yvonne, et al.
Publicado: (2014)

Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease
por: Aichholzer, Freyja, et al.
Publicado: (2021)

Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?
por: Klafki, Hans-Wolfgang, et al.
Publicado: (2022)

N-truncated Aβ(4–x) peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models
por: Wirths, Oliver, et al.
Publicado: (2017)

A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model
por: Stazi, Martina, et al.
Publicado: (2023)

Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS
por: Liepold, Thomas, et al.
Publicado: (2023)

Hippocampal Network Oscillations Rescue Memory Consolidation Deficits Caused by Sleep Loss
por: Ognjanovski, Nicolette, et al.
Publicado: (2018)

Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions
por: Vogelgsang, Jonathan, et al.
Publicado: (2018)

Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Giesers, Naomi K., et al.
Publicado: (2020)

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models
por: Reinert, Jochim, et al.
Publicado: (2016)

A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
por: Spanswick, Simon C., et al.
Publicado: (2011)

Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome
por: Kazim, Syed Faraz, et al.
Publicado: (2017)

Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease
por: Zhang, Ting, et al.
Publicado: (2019)

Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease
por: O'Connor, Margaret, et al.
Publicado: (2020)

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
por: Wirths, Oliver, et al.
Publicado: (2009)

miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease
por: Rodriguez‐Ortiz, Carlos J., et al.
Publicado: (2020)

Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer’s Disease
por: Stazi, Martina, et al.
Publicado: (2020)

The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone‐Induced Central Nervous System Demyelination
por: Tomas‐Roig, Jordi, et al.
Publicado: (2016)

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
por: Hou, Ke, et al.
Publicado: (2020)

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease
por: Liu, Weilin, et al.
Publicado: (2022)

Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice
por: Montenegro, Paola, et al.
Publicado: (2023)

Commentary: The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease
por: Chirumbolo, Salvatore, et al.
Publicado: (2016)

Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer’s disease
por: Ali, Tahir, et al.
Publicado: (2021)

Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease
por: Yan, Shaozhen, et al.
Publicado: (2020)

Genes associated with Alzheimer’s disease affecting ischemic neurodegeneration of the hippocampal CA3 region
por: Pluta, Ryszard, et al.
Publicado: (2020)

How mind-body therapies might reduce pathological features of Alzheimer’s disease
por: Hüttenrauch, Melanie, et al.
Publicado: (2022)

Loss of tau rescues inflammation-mediated neurodegeneration
por: Maphis, Nicole, et al.
Publicado: (2015)

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration
por: Ali, Yousuf O., et al.
Publicado: (2011)

SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease
por: Espinoza, Stefano, et al.
Publicado: (2020)

Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
por: Vyas, Yukti, et al.
Publicado: (2020)

Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
por: Grabrucker, Stefanie, et al.
Publicado: (2023)

Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease
por: Végh, Marlene J, et al.
Publicado: (2014)

Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer’s mouse model
por: Rey, Christophe Clément, et al.
Publicado: (2022)

Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine
por: Choi, Miyeon, et al.
Publicado: (2022)

Hippocampal Volume in Children with Attention Deficit Hyperactivity Disorder and Speech and Language Delay
por: Dhikav, Vikas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_onmnba0si081i7rb649j8llqip