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(18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis

BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to N...

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Autores principales: Kobayashi, Shigeki, Ogura, Mayumi, Suzawa, Naohisa, Horiki, Noriyuki, Katsurahara, Masaki, Ogura, Toru, Sakuma, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070152/
https://www.ncbi.nlm.nih.gov/pubmed/27756255
http://dx.doi.org/10.1186/s12880-016-0161-9
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author Kobayashi, Shigeki
Ogura, Mayumi
Suzawa, Naohisa
Horiki, Noriyuki
Katsurahara, Masaki
Ogura, Toru
Sakuma, Hajime
author_facet Kobayashi, Shigeki
Ogura, Mayumi
Suzawa, Naohisa
Horiki, Noriyuki
Katsurahara, Masaki
Ogura, Toru
Sakuma, Hajime
author_sort Kobayashi, Shigeki
collection PubMed
description BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis. RESULTS: SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. CONCLUSION: Assessment of (18)F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms.
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spelling pubmed-50701522016-10-24 (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis Kobayashi, Shigeki Ogura, Mayumi Suzawa, Naohisa Horiki, Noriyuki Katsurahara, Masaki Ogura, Toru Sakuma, Hajime BMC Med Imaging Research Article BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis. RESULTS: SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. CONCLUSION: Assessment of (18)F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms. BioMed Central 2016-10-18 /pmc/articles/PMC5070152/ /pubmed/27756255 http://dx.doi.org/10.1186/s12880-016-0161-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kobayashi, Shigeki
Ogura, Mayumi
Suzawa, Naohisa
Horiki, Noriyuki
Katsurahara, Masaki
Ogura, Toru
Sakuma, Hajime
(18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title_full (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title_fullStr (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title_full_unstemmed (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title_short (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
title_sort (18)f-fdg uptake in the stomach on screening pet/ct: value for predicting helicobacter pylori infection and chronic atrophic gastritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070152/
https://www.ncbi.nlm.nih.gov/pubmed/27756255
http://dx.doi.org/10.1186/s12880-016-0161-9
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