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(18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis
BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to N...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070152/ https://www.ncbi.nlm.nih.gov/pubmed/27756255 http://dx.doi.org/10.1186/s12880-016-0161-9 |
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author | Kobayashi, Shigeki Ogura, Mayumi Suzawa, Naohisa Horiki, Noriyuki Katsurahara, Masaki Ogura, Toru Sakuma, Hajime |
author_facet | Kobayashi, Shigeki Ogura, Mayumi Suzawa, Naohisa Horiki, Noriyuki Katsurahara, Masaki Ogura, Toru Sakuma, Hajime |
author_sort | Kobayashi, Shigeki |
collection | PubMed |
description | BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis. RESULTS: SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. CONCLUSION: Assessment of (18)F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms. |
format | Online Article Text |
id | pubmed-5070152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50701522016-10-24 (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis Kobayashi, Shigeki Ogura, Mayumi Suzawa, Naohisa Horiki, Noriyuki Katsurahara, Masaki Ogura, Toru Sakuma, Hajime BMC Med Imaging Research Article BACKGROUND: The aim of this study was to determine the value of (18)F-FDG uptake on screening PET/CT images for the prediction of Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis. METHODS: Among subjects who underwent (18)F-FDG PET/CT for cancer screening from April 2005 to November 2015, PET/CT images were analyzed in 88 subjects who had gastrointestinal fiberscopy within 6 months. The volumes of interest (VOIs) were placed in the fornix, corpus and antrum of the stomach to determine maximal standardized uptake value (SUVmax) and mean SUV (SUVmean). Receiver operating characteristic curve (ROC) analysis was performed to determine the diagnostic performance of SUV indicators in predicting H. pylori infection and chronic atrophic gastritis. RESULTS: SUV indicators of the stomach were significantly higher in subjects with H. pylori infection than those without (from P < 0.001 to P < 0.05). ROC analysis revealed that SUVmean had the highest performance in predicting H. pylori infection (AUC 0.807) and chronic atrophic gastritis (AUC 0.784). SUVmean exhibited the sensitivity of 86.5 % and the specificity of 70.6 % in predicting H. pylori infection, and the sensitivity of 75.0 % and 78.6 % in predicting chronic atrophic gastritis. CONCLUSION: Assessment of (18)F-FDG uptake in the stomach reflecting active inflammation is useful in predicting patients with H. pylori infection and subsequent chronic atrophic gastritis which is closely associated with the risk of gastric neoplasms. BioMed Central 2016-10-18 /pmc/articles/PMC5070152/ /pubmed/27756255 http://dx.doi.org/10.1186/s12880-016-0161-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kobayashi, Shigeki Ogura, Mayumi Suzawa, Naohisa Horiki, Noriyuki Katsurahara, Masaki Ogura, Toru Sakuma, Hajime (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title | (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title_full | (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title_fullStr | (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title_full_unstemmed | (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title_short | (18)F-FDG uptake in the stomach on screening PET/CT: value for predicting Helicobacter pylori infection and chronic atrophic gastritis |
title_sort | (18)f-fdg uptake in the stomach on screening pet/ct: value for predicting helicobacter pylori infection and chronic atrophic gastritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070152/ https://www.ncbi.nlm.nih.gov/pubmed/27756255 http://dx.doi.org/10.1186/s12880-016-0161-9 |
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