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Serum C-Reactive Protein in Children with Liver Disease and Ascites

BACKGROUND: The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem. OBJECTIVES: The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease. METHODS...

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Autores principales: Kalvandi, Gholamreza, Honar, Naser, Geramizadeh, Bita, Ataollahi, Maryam, Rahmani, Asghar, Javaherizadeh, Hazhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070613/
https://www.ncbi.nlm.nih.gov/pubmed/27795726
http://dx.doi.org/10.5812/hepatmon.38973
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author Kalvandi, Gholamreza
Honar, Naser
Geramizadeh, Bita
Ataollahi, Maryam
Rahmani, Asghar
Javaherizadeh, Hazhir
author_facet Kalvandi, Gholamreza
Honar, Naser
Geramizadeh, Bita
Ataollahi, Maryam
Rahmani, Asghar
Javaherizadeh, Hazhir
author_sort Kalvandi, Gholamreza
collection PubMed
description BACKGROUND: The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem. OBJECTIVES: The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease. METHODS: In this study, 150 children diagnosed with liver disease and ascites upon admission to Nemazee Teaching Hospital (Shiraz, Iran) were examined. Patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the PMN count ≥ 250/mm(3) in the ascetic fluids. Routine laboratory tests were conducted and quantitative C-reactive protein (CRP) levels were measured for all of the patients. Accuracy, sensitivity, and specificity of CRP was evaluated for diagnosis of SBP. RESULTS: Of 150 cirrhotic patients, 109 patients presented without SBP (52.29% male, mean age: 5.02 ± 4.49 years) and 41 patients presented with SBP (51.21% male, mean age: 4.71 years). Cell counts, protein levels, albumin levels, and lactate dehydrogenize (LDH) levels of the ascetic fluid and serum samples in the SBP group were higher than the rates for those without SBP (P < 0.05(. The mean ± SD of CRP in the SBP group (36.89 ± 23.43) increased significantly compared to the rate among those without SBP (21.59 ± 15.43, P = 0.001). The percentages for sensitivity and specificity of CRP, the diagnosis of SBP based on the PMN count ≥ 250/mm(3), and cultured ascites were 69.23%, 90.25%, 88.43%, and 84.32%, respectively. The areas under the curve of CRP for SBP based on the PMN count ≥ 250/mm(3) and cultured ascites was 0.94 (CI 95%: 0.90 to 0.96) and 0.85 (CI 95%: 0.84 to 0.92), respectively (P < 0.001). CONCLUSIONS: Our study showed that CRP is a marker with high sensitivity and specificity for the diagnosis of SBP in cirrhotic children.
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spelling pubmed-50706132016-10-28 Serum C-Reactive Protein in Children with Liver Disease and Ascites Kalvandi, Gholamreza Honar, Naser Geramizadeh, Bita Ataollahi, Maryam Rahmani, Asghar Javaherizadeh, Hazhir Hepat Mon Research Article BACKGROUND: The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem. OBJECTIVES: The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease. METHODS: In this study, 150 children diagnosed with liver disease and ascites upon admission to Nemazee Teaching Hospital (Shiraz, Iran) were examined. Patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the PMN count ≥ 250/mm(3) in the ascetic fluids. Routine laboratory tests were conducted and quantitative C-reactive protein (CRP) levels were measured for all of the patients. Accuracy, sensitivity, and specificity of CRP was evaluated for diagnosis of SBP. RESULTS: Of 150 cirrhotic patients, 109 patients presented without SBP (52.29% male, mean age: 5.02 ± 4.49 years) and 41 patients presented with SBP (51.21% male, mean age: 4.71 years). Cell counts, protein levels, albumin levels, and lactate dehydrogenize (LDH) levels of the ascetic fluid and serum samples in the SBP group were higher than the rates for those without SBP (P < 0.05(. The mean ± SD of CRP in the SBP group (36.89 ± 23.43) increased significantly compared to the rate among those without SBP (21.59 ± 15.43, P = 0.001). The percentages for sensitivity and specificity of CRP, the diagnosis of SBP based on the PMN count ≥ 250/mm(3), and cultured ascites were 69.23%, 90.25%, 88.43%, and 84.32%, respectively. The areas under the curve of CRP for SBP based on the PMN count ≥ 250/mm(3) and cultured ascites was 0.94 (CI 95%: 0.90 to 0.96) and 0.85 (CI 95%: 0.84 to 0.92), respectively (P < 0.001). CONCLUSIONS: Our study showed that CRP is a marker with high sensitivity and specificity for the diagnosis of SBP in cirrhotic children. Kowsar 2016-07-23 /pmc/articles/PMC5070613/ /pubmed/27795726 http://dx.doi.org/10.5812/hepatmon.38973 Text en Copyright © 2016, Kowsar Corp http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Kalvandi, Gholamreza
Honar, Naser
Geramizadeh, Bita
Ataollahi, Maryam
Rahmani, Asghar
Javaherizadeh, Hazhir
Serum C-Reactive Protein in Children with Liver Disease and Ascites
title Serum C-Reactive Protein in Children with Liver Disease and Ascites
title_full Serum C-Reactive Protein in Children with Liver Disease and Ascites
title_fullStr Serum C-Reactive Protein in Children with Liver Disease and Ascites
title_full_unstemmed Serum C-Reactive Protein in Children with Liver Disease and Ascites
title_short Serum C-Reactive Protein in Children with Liver Disease and Ascites
title_sort serum c-reactive protein in children with liver disease and ascites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070613/
https://www.ncbi.nlm.nih.gov/pubmed/27795726
http://dx.doi.org/10.5812/hepatmon.38973
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