Cargando…

Regulation of amyloid precursor protein processing by its KFERQ motif

Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer’s disease (AD). Here, we found that APP contains KFERQ motif at its C-terminus, a consen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Ji-Seon, Kim, Dong-Hou, Yoon, Seung-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070722/ https://www.ncbi.nlm.nih.gov/pubmed/26779997 http://dx.doi.org/10.5483/BMBRep.2016.49.6.212

Ejemplares similares

Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting
por: Kacal, Merve, et al.
Publicado: (2021)

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein
por: Kim, Jiyoung, et al.
Publicado: (2013)

Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling
por: Pimenova, Anna A., et al.
Publicado: (2014)

Secretases Related to Amyloid Precursor Protein Processing
por: Liu, Xiaoling, et al.
Publicado: (2021)

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex
por: Jaeger, Philipp A., et al.
Publicado: (2010)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration
por: Ahn, Ji-Hwan, et al.
Publicado: (2016)

Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing
por: Liu, Chia-Chen, et al.
Publicado: (2012)

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing
por: Niederst, Emily D., et al.
Publicado: (2015)

Amyloid precursor protein and its interacting proteins in neurodevelopment
por: Chau, Dennis Dik-Long, et al.
Publicado: (2023)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
por: Jung, Eun Sun, et al.
Publicado: (2015)

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation
por: Bergström, Petra, et al.
Publicado: (2016)

Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein☆
por: Liu, Runzhong, et al.
Publicado: (2013)

Herpes simplex virus interferes with amyloid precursor protein processing
por: Shipley, Suzanne J, et al.
Publicado: (2005)

Altered Processing of Amyloid Precursor Protein in Cells Undergoing Apoptosis
por: Fiorelli, Tina, et al.
Publicado: (2013)

The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein
por: Seipold, Lisa, et al.
Publicado: (2016)

Sulfuretin exerts diversified functions in the processing of amyloid precursor protein
por: Chen, Jian, et al.
Publicado: (2020)

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation
por: Arbor, Sage
Publicado: (2017)

The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif
por: Eggert, Simone, et al.
Publicado: (2020)

The paradigm of amyloid precursor protein in amyotrophic lateral sclerosis: The potential role of the (682)YENPTY(687) motif
por: Matrone, Carmela
Publicado: (2023)

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
por: Yang, Miao, et al.
Publicado: (2013)

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
por: Scholefield, Zoe, et al.
Publicado: (2003)

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
por: Hamilton, D. Lee, et al.
Publicado: (2014)

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer’s disease transgenic mouse model
por: Zhang, She-Qing, et al.
Publicado: (2013)

Interactions between amyloid, amyloid precursor protein, and mitochondria
por: Wilkins, Heather M.
Publicado: (2023)

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development
por: Ramaker, Jenna M., et al.
Publicado: (2016)

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes
por: Del Prete, Dolores, et al.
Publicado: (2016)

Corrigendum: The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein
por: Seipold, Lisa, et al.
Publicado: (2017)

TDP-43 and amyloid precursor protein processing: implications for Alzheimer’s disease
por: Hicks, David A.
Publicado: (2020)

Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein
por: Lin, Tong, et al.
Publicado: (2022)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Data on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice
por: Xu, Feng, et al.
Publicado: (2015)

MDGA1 negatively regulates amyloid precursor protein–mediated synapse inhibition in the hippocampus
por: Kim, Jinhu, et al.
Publicado: (2022)

A novel mechanism for the regulation of amyloid precursor protein metabolism
por: Chen, Qi, et al.
Publicado: (2002)

Role of amyloid precursor protein (APP) in regulation of neuronal genes
por: Nalivaeva, Natalia N.
Publicado: (2015)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
por: Jung, Joo In, et al.
Publicado: (2014)

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
por: Tam, Joshua HK, et al.
Publicado: (2014)

Biology and pathophysiology of the amyloid precursor protein
por: Zheng, Hui, et al.
Publicado: (2011)

Amyloid Precursor Protein and Alzheimer’s Disease
por: Orobets, Kseniia S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jh6rn60969himahpp6rhe4a0dh