Cargando…

Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line

BACKGROUND: Prolyl oligopeptidase (POP) is a serine endopeptidase that is widely distributed in vivo, particularly in the liver. Significant changes in functional mitochondrial proteins involved with mitochondrial oxidoreductases/transporters and nucleic acid binding proteins were observed after POP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Da, Li, Bing-Hang, Wang, Jing, Ding, Yong-Nian, Dong, Yan, Chen, Yuan-Wen, Fan, Jian-Gao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070736/ https://www.ncbi.nlm.nih.gov/pubmed/27760195 http://dx.doi.org/10.1371/journal.pone.0165224

Ejemplares similares

Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis
por: Tenorio-Laranga, Jofre, et al.
Publicado: (2010)

The role of prolyl oligopeptidase, understanding the puzzle
por: García-Horsman, J. Arturo
Publicado: (2020)

Inhibition of Prolyl Oligopeptidase Prevents Consequences of Reperfusion following Intestinal Ischemia
por: Filippone, Alessia, et al.
Publicado: (2021)

Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
por: Harwood, Adrian J
Publicado: (2011)

Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro
por: Cucinotta, Laura, et al.
Publicado: (2023)

Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase
por: Czekster, Clarissa M., et al.
Publicado: (2017)

Intrinsic basis of thermostability of prolyl oligopeptidase from Pyrococcus furiosus
por: Banerjee, Sahini, et al.
Publicado: (2021)

Crystal Structures of Trypanosoma brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes
por: Canning, Peter, et al.
Publicado: (2013)

The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis
por: Waumans, Yannick, et al.
Publicado: (2015)

Distribution, classification, domain architectures and evolution of prolyl oligopeptidases in prokaryotic lineages
por: Kaushik, Swati, et al.
Publicado: (2014)

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo
por: Svarcbahs, Reinis, et al.
Publicado: (2018)

The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes
por: Luo, Hong, et al.
Publicado: (2018)

Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum
por: Hellinger, Roland, et al.
Publicado: (2015)

The Protective Role of Prolyl Oligopeptidase (POP) Inhibition in Kidney Injury Induced by Renal Ischemia–Reperfusion
por: Casili, Giovanna, et al.
Publicado: (2021)

Exploration of the One-Bead One-Compound Methodology for the Design of Prolyl Oligopeptidase Substrates
por: Comellas, Gemma, et al.
Publicado: (2009)

Analysis of salt-bridges in prolyl oligopeptidase from Pyrococcus furiosus and Homo sapiens
por: Bandyopadhyay, Amal Kumar, et al.
Publicado: (2019)

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae)
por: Siatka, Tomáš, et al.
Publicado: (2017)

Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection
por: Lasse, Camila, et al.
Publicado: (2020)

Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase
por: Gattringer, Jasmin, et al.
Publicado: (2021)

The Inhibition of Prolyl Oligopeptidase as New Target to Counteract Chronic Venous Insufficiency: Findings in a Mouse Model
por: Casili, Giovanna, et al.
Publicado: (2020)

The protective role of prolyl oligopeptidase (POP) inhibition in acute lung injury induced by intestinal ischemia-reperfusion
por: Casili, Giovanna, et al.
Publicado: (2021)

Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy
por: Cui, Hengjing, et al.
Publicado: (2021)

Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia
por: Vila, Èlia, et al.
Publicado: (2023)

Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis
por: Bastos, I.M.D, et al.
Publicado: (2013)

Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages
por: Portugal, Brina, et al.
Publicado: (2017)

Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia
por: Zolotov, Nikolay N., et al.
Publicado: (2021)

New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro
por: Kumar, Raj, et al.
Publicado: (2017)

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease
por: Norrbacka, Susanna, et al.
Publicado: (2019)

Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages
por: Olivo, R. A., et al.
Publicado: (2008)

Diversity of MSDIN family members in amanitin-producing mushrooms and the phylogeny of the MSDIN and prolyl oligopeptidase genes
por: He, Zhengmi, et al.
Publicado: (2020)

Directed-Mutagenesis of Flavobacterium meningosepticum Prolyl-Oligopeptidase and a Glutamine-Specific Endopeptidase From Barley
por: Osorio, Claudia E., et al.
Publicado: (2020)

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner
por: Julku, Ulrika H., et al.
Publicado: (2021)

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
por: Pätsi, Henri T., et al.
Publicado: (2021)

Structural Analysis of Prolyl Oligopeptidases Using Molecular Docking and Dynamics: Insights into Conformational Changes and Ligand Binding
por: Kaushik, Swati, et al.
Publicado: (2011)

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors
por: Fajtová, Pavla, et al.
Publicado: (2015)

Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase()
por: Jackson, Kenneth W., et al.
Publicado: (2015)

Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase
por: Kulkarni, Apoorva M., et al.
Publicado: (2021)

KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation
por: Scuderi, Sarah Adriana, et al.
Publicado: (2021)

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients
por: Tenorio-Laranga, Jofre, et al.
Publicado: (2015)

Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation
por: Jiang, Dai-Xi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rkat62o7uad3qj10gv6hsh6kg7